Depends on the qualities of the individual girl. If she’s really explosive, you have the option of going S2L or concurrent (as per my 400m system) because any blunting of top speed will be fairly quickly restored when the emphasis reverts to high intensity and longer recoveries.
The last time I coached actively was for the Atlanta OG and I was asked to prepare a young woman for the 4x4.
She followed the system advocated in this thread: She ended up making both the 4x1 and 4x4 teams, which was a surprise to some.
The 4x1 side made the Olympic final and she ran both the heat and final on the backstraight and lost only 0.2sec on the fly to the US rep who, if memory doesn’t betray me, was someone named Devers.
Of course had they raced off the blocks, I think it would have been ugly but on the fly my lady’s weakness was pretty much removed. She also ran the fastest split for her 4x4 team.