Pharmacological levels of thiamin are used in the treatment of certain inborn errors of metabolism. One variant form of MSUD has been shown to respond to oral thiamin supplements (up to 500 mg daily). Other metabolic diseases that may respond to large doses of the vitamin are thiamin-responsive megaloblastic anemia id and thiamin-responsive lactic acidosis. In the latter condition, large doses of thiamin can increase the activity of pyruvate dehydrogenase in the liver, thereby decreasing the level of lactic acid, as more pyruvate is decarboxylated for entry into the Krebs cycle .
trying to do some basic research on lactic acid buildup…wondering if anyone takes vit b complex to help decrease lactic acid…or does anyone else take or know of supps that delay or offset la buildup
One note though is that animal studies in racehorses have shown that muscle carnosine concentrations are higher in muscles with a high percentage of fast-twitch glycolytic fibers and lower in muscles with predominantly slower twitch oxidative fiber types. Carnosine accounts for about 10%-40% of the pH-buffering capacity of muscle. So realistically (in horses at least) adding more carnosine to your diet could theoretically increase your ability to train longer at high intensity.
Ciwujia is old-school (remember Endurox?). It’s a chinese herb. In-vitro studies in Japan looked promising back in the day, but I haven’t seen anything on it lately.