ESTI would be a good person to talk to about this.
I know he used a combination of KitKat’s GPP along with Charlie’s short to long program with some of his high school kids to good effect. I can tell you from experience that when you test the 60, 150, and 300 at the end of the first six week block, don’t expect much change in the 60 time, the 150 will improve a bit, but the 300 will drop considerably. I find it also teaches people how to run relaxed, so the first six week block could be done more or less as is as a general conditioning block, with some modifications in the second GPP block adding in an acceleration day out to 60m and taking out some of the lactic work depending on athlete age and experience levels.
Alternatively, you may wish to put in an acceleration / max velocity in day once per week right from the first block- I think that’s what ESTI did. As long as you understand that KitKat’s GPP is very 400m oriented and doesn’t contain any true speed work, you will know that you have to add some alactic speed in to benefit the 100m athlete.
P.S. The Lactate Threshold ebook is an amazing read, and even if you don’t plan to run the 400 it’s highly recommended. It’s much easier to read than the thread. I downloaded it to my tablet and read it a dozen times. It is packed with info!