Me personally I only use the leg press for unilateral hypertrophy work. Regardless, I don’t like to use it for much else because the the way the machine is built it does most of the work for you which is why Body builders can stack the weight full AND have their friends stand on it and do that for reps/sets!
http://www.metacafe.com/watch/2537988/ronnie_coleman_2300_lb_leg_press/