Hyperplasia

[Dazed]

@fogelson

I have logic in quotes because the body doesn’t always work or even necessarily normally by proliferating cells in response to a stimulus (as it often isn’t the most efficient way) and the way he expressed it seems to suppose that this would be a logical way for things to work (he is also leaving out aspects of mitochondria within muscle cells, but no need to go that far now). Plus, muscle cells are inherently different than other tissues in the body in that they have (better to say can have) multiple nuclei. On top of that, who is to say hyperplasia is necessarily more beneficial over increasing the size of the fibers?

I just don’t see a basis for the claims or arguments.

I can accept that my argument was based on some fairly basic, but not altogether unwarranted, assumptions but if you have reason to refute them as you apparently do, why not share them rather than listing some very general attributes of muscles cells.

Logic is only as good as the information that you have at hand, perhaps you can fill me in on the complicating factors you briefly mentioned.

I’m interested in why you propose multiple nuclei and mitochondria help the cell overcome the inherent problem of transport caused by increased cell volumes. As muscle volume increases does the number of nuclei increase to accommodate the greater signaling needs of the muscle? What does the literature say about the mechanisms designed to overcome the problems I have described?

I am limited to my understanding of physics and maths in this area so please forgive my ignorance.