Think about all the differences here. Assuming a high level athlete who can accelerate say 40m before hitting top speed.
3x4x50m = 480m Acceleration, 120m upright. Highest top speed = 11m/s
3x200m = 120m acceleration, 480m upright.
Highest top speed = 10.5m/s (because you are accelerating on a bend)
That’s a totally different training impact just from the types of muscle groups you are using let alone from a metabolic or neural perspective or even then from a technical perspective (200m practices running on a bend and under fatigue at the end, 50m practices acceleration and reaching top speed).