Coenzyme Q10 (Ubiquinone)

Has anyone tried Coenzyme Q10 (Ubiquinone)?

I know it’s for energy production & helps transfer electrons w/in the body.

Any results or studies on athletes?

Kenny Mac~~

CO Q-10 is an antioxidant am i correct? Kenny not to hijack your thread but do any memebers use antioxidants or feel there is a need for them?

Antioxidants cuts the free radicals and other toxic chemicals in the body to my understanding.

Kenny Mac~~~

I have previously taken Q10 and have just started taking it again.

I am taking 50mg dose in tablet form.

I have noticed a difference in taking them especially during more stressful times.

No evidence but they seemed to work with me. I also take a multi vitamin and glucsomaine in a powder form daily.

ive got a few of my triathletes on co-Q10. a good anti Ox but i think its taken mainly to help with heart function…?

The Mitochondria and coenzyme Q10 get overlooked

A key mitochondrial antioxidant produced naturally in the body which can be taken in supplemental form is coenzyme Q10. CoQ10 is essential for the transport of electrons inside the mitochondria. [Clin Investig 71: S55-9, 1993] CoQ10 increases mitochondrial respiration and production of ATP cell energy. [Cell Mol Biol 43:741-9, 1997]

Mutations in mitochondrial DNA may lead to reduced ATP energy levels in living cells which can sometimes be corrected with supplemental coenzyme Q10. [Ann Clin Lab Sci 31:25-67, 2001]

When living cells are deprived of oxygen, as seen in tumor cells (called hypoxia), then ATP cell energy levels decline rapidly. The provision of supplemental CoQ10 has been shown to facilitate resynthesis of ATP in functionally impaired mitochondria. [Arch Int Pharmacodyn Ther 287: 96-108, 1987; Surgery 91:631-7, 1982]

A deficiency of coenzyme Q10 has been described in aging, cancer and when statin cholesterol-lowering drugs are employed. [J Am Coll Nutr 20: 591-98, 2001]

For example, CoQ10 levels in tissue of breast cancer patients are significantly decreased compared to surrounding tissues. [Clin Biochem 33: 279-84, 2000] Breast cancer patients are more likely to exhibit low CoQ10 levels than healthy people. [Biochem Biophys Rres Commun 234: 296-99, 1997]

The provision of supplemental CoQ10 (390 mg) to breast cancer patients has been shown to induce complete regression in some cases. [Biochem Biophys Res Comm 199: 1504-08, 1994; 212: 172-77, 1995] Though only a small group study, the provision of an array of antioxidant supplements including coenzyme Q10 to high risk breast cancer patients has been demonstrated to be beneficial in reducing mortality, spread of cancer and quality of life. [Mol Aspects Med 15: 231-40S, 1994]

Statin cholesterol-lowering drugs are known to deplete the body of coenzyme Q10. Thus, it would be of interest to investigate whether cancer rates are higher among statin drug users. Surprisingly, some studies champion statin drugs as novel anti-cancer agents. [Clin Cancer Res 7:2067-75, 2001] Over a five-year period, one study did not confirm any association between statin drugs and the risk of cancer. [Am J Med 15;110: 716-23, 2001] But other disturbing studies do confirm a relationship between statin drug use and breast and prostate cancer. [Epidemiology 13: 262-67, 2002] More studies are underway.

Coenzyme Q10 plays vital roles in oxidative phosphorylation to supply ATP. It also acts as an antioxidant protecting various structures eg. LDL cholestrol. It is administered to patients with various heart problems, certain cancers, and other diseases, but regarding studies with athletes and improving performance the results of coenzyme Q10 supplementation are mixed.

athletic performance refs:

general coenzyme q10 info: