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No, because there aren’t any.
The supplement market is driven by hype and demand, not by good science.
argining does jack squat unless you have heart disease and the NO products continue b/c idiot bodybuilders continue to buy them. not becuase they work. becuase they don’t. you wanna raiase NO before workout? drink some carbs and protein to raise insulin, that’ll drive NO and give you an anabolic response from eating nutrients
glutamine has shown to be ineffective as an anabolic, for fat loss or for sparing muscle on a diet. it’s only use might be to protect the immune system during peiods of high volume training and that’s more for endurance weenies
Lyle
I read a study once claiming that taking 1200mg of l-arganine with 1200mg of l-lysine increased GH and IGF-1 levels significantly… I’ll try and dig it up.
Biochemical and Molecular Action of Nutrients
Dietary Glutamine Enhances Murine T-Lymphocyte Responsiveness1Samantha Kew, Sharon M. Wells, Parveen Yaqoob3, Fiona A. Wallace, Elizabeth A. Miles and Philip C. Calder2
Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
2To whom correspondence and reprint requests should be addressed.
To examine the effects of dietary glutamine on lymphocyte function, male mice aged 6 wk were fed for 2 wk one of three isonitrogenous, isocaloric diets, which varied in glutamine concentration. The control diet included 200 g casein/kg, providing 19.6 g glutamine/kg; the glutamine-enriched diet provided 54.8 g glutamine/kg partly at the expense of casein; and the alanine + glycine-enriched diet provided 13.3 g glutamine/kg. The plasma concentrations of a number of amino acids varied because of the diet fed. The plasma glycine concentration was greater in mice fed the alanine + glycine-enriched diet (380 ± 22 µmol/L) than in mice fed the control (177 ± 17 µmol/L) or the glutamine-enriched (115 ± 18 µmol/L) diets. The plasma glutamine concentration was greater in mice fed the glutamine-enriched diet (945 ± 117 µmol/L) than in those fed the diet enriched with alanine + glycine (561 ± 127 µmol/L), but was not different from that in mice fed the control diet (791 ± 35 µmol/L). There was a significant linear relationship between the amount of glutamine in the diet and plasma glutamine concentration (r = 0.655, P = 0.015). Plasma alanine concentration was unaffected by diet. The reason for the lack of effect of increasing the amount of alanine in the diet upon its concentration in the circulation may relate to its use by the liver. Thymidine incorporation (56 ± 18 kBq/well versus <10 kBq/well), expression of the {alpha}-subunit of the interleukin-2 receptor (62 versus 30% receptor positive cells) and interleukin-2 production [189 ± 28 versus 106 ± 5 (control) or 61 ± 13 (alanine + glycine enriched) ng/L] were greater for concanavalin A-stimulated spleen lymphocytes from mice fed the glutamine-enriched diet compared to those from mice fed the other two diets. Thus, increasing the amount of glutamine in the murine diet enhances the ability of T lymphocytes to respond to mitogenic stimulation. Taken together, these observations suggest that increasing the oral availability of glutamine could promote the T-cell driven, cell-mediated immune response.
The above studies show the role of glutamine in boosting the immune system. Increased lymphocytes are likely to reduce susceptibility to upper respiratory tract infection. Plasma glutamine concentrations are known to decrease after intense exercise, thereby supplementation seems to be a good idea. Research also exists showing that glutamine supplementation can counteract the protein synthesis decline. Other data that I came across shows glut supp post exercise promotes muscle glycogen accumulation.
I prefer to talk about joint angles, nutrition supp’s are over reacted.
Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men
Campbell, B
4g in short showed significant differences @ the .05 level in strength tests as well as blood levels and subjects showed toleration of that dose level.
Growth hormone, arginine and exercise
Kanaley, JA
Basically states oral arginine at rest increases growth hormone release two fold. But during exercise may release it slower than exercise alone.
Starving yourself increases GH…
Arginine is the test for GH deficiency. IV arginine is given and if there isn’t a significant boost in GH levels, it’s considered proof of a pituitary problem.
I suspect that’s part of the thinking behind using glutamine or essential AAs at night- reduced blood sugar boosts GH but the AAs are available to replace those mobilized in the fasting state. everything is a balancing act and I think there will be no single route for everyone.
How fast do you put on muscle?
How is your weight- trouble putting it on or keeping it off? etc etc
Immune system issues apply to all events including sprinting if you go over the top. You of course strive not to- but factors beyond the control of the coach also come into play away from training as well.
Charlie wrote:
“AAs are available to replace those mobilized in the fasting state”
I thought that fasting was a no-no for sprinters. (?)